Three service members with the International Security Assistance Force died Friday in separate attacks, NATO officials said.
Two died in southern Afghanistan - one in an insurgent attack; the other in a roadside bombing; the force said. The third died in a roadside bombing in eastern Afghanistan.
In keeping with its policy, the force did not release the soldiers' names or nationalities.
The deaths come a day after three NATO-led service members were killed: two in the south and another in the east, the force said.
This year is already the deadliest for coalition and U.S. forces since the battle against the Taliban started some nine years ago.
Last year, 516 coalition troops were killed in Afghanistan. More than 600 have died so far in 2010, according to a CNN tally.
The morbid milestone comes as the United States is making a strong effort to fight the Taliban.
U.S. President Barack Obama ordered the deployment of 30,000 extra U.S. forces to Afghanistan this year, increasing the total American troop commitment to almost 100,000. At least 25 other countries pledged an additional 7,000 troops.
The international alliance was formed under a U.N. mandate to bolster a secure environment and support the reconstruction of Afghanistan. NATO took command in 2003.
The force comprises troops from dozens of countries.